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The exam is inadequate for particular classes of medicines together with radiopharmaceuticals, most cancers chemotherapeutic agents, hypnotics and narcotics, vitamins, steroids and particular antibiotics. It has been found that apparent pyrogens in the item could be "masked" with the physio-chemical activity from the therapeutic drug components. On top of that, the rabbit test is insufficiently delicate for endotoxin detection in intrathecal drug solutions.
There are actually other less widespread strategies used for eliminating endotoxins. Within the manufacture of sterile powders, crystallization or purification is usually utilized to get rid of endotoxins.
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